Enhancing the antimicrobial activity of silver nanoparticles ...

With the growing concerns about antibiotic resistance, the need for alternative antimicrobial agents is more pressing than ever. Recent developments in nanotechnology have opened new pathways for enhancing antimicrobial activity, particularly through the use of silver nanoparticles (AgNPs). This article explores how tea extracts can efficiently increase the antimicrobial efficacy of AgNPs against pathogenic bacteria, particularly the drug-resistant ESKAPE group.

Introduction

The rise of multidrug-resistant microorganisms presents significant challenges within healthcare. The escalating overuse of antibiotics has led to increased levels of resistance, resulting in conditions that cost millions of dollars annually in healthcare alone. The need for innovative solutions cannot be overstated.

Application of Silver Nanoparticles

Among various nanoparticles, silver nanoparticles have attracted considerable attention for their antiviral, antibacterial, and antifungal properties. The antimicrobial properties of silver nanoparticles are already well documented. These nanoparticles exert their bactericidal action by compromising microbial cell integrity through interactions with cell membranes and inducing oxidative stress.

Synthesis of Silver Nanoparticles using Tea Extracts

Additionally, the incorporation of tea extracts serves a dual purpose: it not only stabilizes and reduces silver ions to AgNPs but also adds additional antimicrobial properties from the tea's phytochemicals. The combination of AgNPs and tea extracts presents a promising strategy to combat microbial infections.

Experimental Methods

We synthesized AgNPs using three different tea extracts—black, green, and red tea—through an environmentally friendly approach. Various antimicrobial tests were conducted using resistant strains of ESKAPE bacteria, revealing significant improvements in the antimicrobial efficacy when AgNPs were combined with tea extracts.

Results

Results indicated that the synthesized silver nanoparticles exhibited enhanced antibacterial properties against ESKAPE pathogens. The efficacy of G-TeaNPs (silver nanoparticles synthesized from green tea extracts) was particularly remarkable, resulting in high levels of bacterial cell death. This finding suggests that tea extracts contribute significantly to the overall antimicrobial effectiveness of AgNPs.

Conclusions

The findings indicate that synthesizing silver nanoparticles with tea extracts yields a promising method to increase antibacterial activity, particularly against drug-resistant strains. By employing these green-synthesized nanoparticles, researchers and health professionals can explore new avenues in the fight against infections. The efficiency demonstrated by the combination of tea extracts and silver nanoparticles reinforces the potential for innovative methods to tackle antimicrobial resistance.

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