PHOSPHATIDYLSERINE - Uses, Side Effects, and More

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FDA. Qualified Health Claim: Final Decision Letter - Phosphatidylserine and Cognitive Dysfunction and Dementia. May . Available at: https://wayback.archive-it.org///https://www.fda.gov/Food/IngredientsPackagingLabeling/LabelingNutrition/ucm.htm. Accessed on March 18, .

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Palmieri G, Palmieri R, Inzoli MR, et al. Double-blind controlled trial of phosphatidylserine in patients with senile mental deterioration. Clin Trials J ;24:73-83.

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Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geriatr Cogn Disord. ;38(1-2):39-45. View abstract.

Villardita C, Grioli S, Salmeri G, et al. Multicentre clinical trial of brain phosphatidylserine in elderly patients with intellectual deterioration. Clin Trials J ;24:84-93.

Wells AJ, Hoffman JR, Gonzalez AM, et al. Phosphatidylserine and caffeine attenuate postexercise mood disturbance and perception of fatigue in humans. Nutr Res ;33:464-72. View abstract.

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Phosphatidylserine is a greasy substance known as a phospholipid.

Every single cell in your body produces phosphatidylserine. The phospholipid helps protect and cover cells from attackers. Your blood cells use it to clot properly if you&#;re injured, and your brain uses it to make it easier to send messages between neurons.  

You can find phosphatidylserine in some foods &#; such as soybeans, egg yolks, and liver. It&#;s also available as a supplement in powder and capsule forms. Eating phosphatidylserine may offer health benefits, particularly for your brain. 

Health Benefits

The vitamins, minerals, and micronutrients in phosphatidylserine provide some important health benefits. Phosphatidylserine is known to act as an antioxidant, helping reduce the effects of dangerous free radicals on your body. This can help reduce your risk of developing conditions like diabetes and cancer.

Consuming phosphatidylserine can lead to several health benefits:

Reduced Muscle Fatigue and Soreness

Large amounts of phosphatidylserine &#; up to 800 milligrams daily &#; may be linked to better recovery after heavy exercise.

Studies suggest that supplementing your diet with large amounts of phosphatidylserine can help decrease muscle soreness and reduce the number of stress hormones your body releases during and after physical activity. This can result in a more pleasant exercise experience.

Reduced Inflammation

Phosphatidylserine may help reduce inflammation symptoms of several chronic conditions. Chronic inflammation is linked to many potential health problems &#; such as heart disease, diabetes, and arthritis.

Studies suggest that getting enough phosphatidylserine to your diet can help reduce markers of chronic inflammation, lowering your risk of negative health effects. However, the topic would benefit from further research that includes human subjects.

Improved Memory

Because of phosphatidylserine&#;s important role in brain signaling, it isn&#;t surprising that some studies show the nutrient improves memory.

In people with mild symptoms of Alzheimer&#;s disease, diet supplementation with phosphatidylserine improved memory and cognitive abilities. However, it does appear that these effects wear off after supplementation stops. It may be important to continue taking phosphatidylserine to reduce symptoms of Alzheimer&#;s.

Depression Management

Early studies suggest that phosphatidylserine may help reduce depression, especially in people over the age of 65. This phospholipid is theorized to help the brain regulate mood, and it&#;s known that phosphatidylserine levels tend to drop as people get older.

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