Being a warm-blooded (or homeothermic) animal, we humans have a built-in sensory process called thermo-reception. This is how we detect different levels of temperatures in the environment and the body.

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This process helps us to maintain considerable inner physiological stability (e.g., body temperature and metabolism) under changing environmental conditions.

How Do We Perceive Temperature?

Different sensors perceive different temperatures. We perceive external temperature via thermoreceptors in our skin, which, in response to temperature stimuli, fires a specific neural pathway that carries a representation of thermosensory activity to the cerebral cortex in our forebrain.

These receptors are, as you guessed, specific places in our skin that are selectively sensitive to warm or cold stimuli.

What Temperature Range Can We Sense?

The cold spots on our skin fire when temperatures go below the neutral skin temperature (~34 °C [93 °F]). Likewise, the warm spots have increased activity at temperatures warmer than neutral skin temperature.

The sensitivity of these receptors extends across a continuum of thresholds and response maxima. The static activity of many cold receptors reaches a peak at temperatures around 20&#;30 °C (68&#;86 °F).

Some receptors have lower thresholds (i.e., less than 30 °C [86 °F]) and maximal activity at colder temperatures (i.e., less than 20 °C [68 °F]).

Warm receptors are continuously active at constant temperatures above neutral skin temperature and have response maxima around 41&#;46 °C (106&#;115 °F), although, in many cases, warm receptors are inactive at temperatures above 45 °C (113 °F).

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Pain receptors called thermal nociceptors fire signals when the temperature is over 45 °C and less than five °C (these values change slightly depending on the source). These signals are what we experience as pain.

What Are Our Temperature Receptors?

The sensory system involved in perceiving the changes in skin temperature begins with the free nerve endings found in the dermal and epidermal layers of skin that can be functionally classified as cold and warm thermoreceptors.

Warm and cold receptors respond similarly to radiant and conducted thermal energy and are involved in perceiving innocuous (harmless) temperatures.

The molecular mechanisms underlying temperature sensation have been extensively studied over the past decade. As a result, several temperature-sensitive ion channels of the transient receptor potential (TRP) family have been identified as candidate temperature sensors.

These thermos TRP channels are expressed in sensory nerve endings and are active at specific temperatures ranging from noxious cold to burning heat.

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